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Strengths and limitations This study had many strengths, a nationally representative US sample, choice of a well-validated measure of global health that includes a physical and mental component 17,35 , testing of the associations between a novel smoking-descriptor (childhood smoking) and poor HRQOL, adjustment for many other aspects of cigarette smoking that also independently relate to HRQOL, and a sensitivity analysis that appropriately considers smoking-related disease measures as mediators rather than independent risk factors

The investigators concluded that redefining B12 deficiency around functional biomarkers could allow earlier intervention and the prevention of cognitive decline

but, unfortunately for mankind, unattainable

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